34 - 26 
The Cardinals came out victorious in a wild game against Orange. Louisville won the game 34-26. The game had 51 points scored in the first half, but only 9 points scored in the second half. Louisville quarterback Lincoln Kienholz threw for 310 yards and one touchdown and also ran for 53 yards and two touchdowns. Running back Keyjuan Brown ran the ball 13 times for 50 yards and two touchdowns. For Syracuse, Malachi Nelson started at quarterback for the second straight week and threw for 315 yards and two touchdowns on 26 of 39 passes. Wide receiver Umari Hatcher caught 13 passes for 224 yards and a touchdown. Running back Ahmad Miller ran the ball 18 times for 123 yards and a touchdown.
