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Boston College
| Player | Injury | Status | Details |
|---|---|---|---|
| Amari Jackson (DB) | Undisclosed | Questionable | |
| Bryce Dopson (WR) | Undisclosed | Out | |
| Cameron Martinez (DB) | Undisclosed | Out | |
| Danny Edgehille (TE) | Undisclosed | Out | |
| Daveon Crouch (LB) | Undisclosed | Out | |
| Jaedn Skeete (WR) | Shoulder | Out | |
| Jaylen Blackwell (LB) | Undisclosed | Out | |
| Max Tucker (DB) | Undisclosed | Probable | |
| Omar Thornton (DB) | Undisclosed | Probable | |
| Syair Torrence (DB) | Undisclosed | Out |
Clemson
| Player | Injury | Status | Details |
|---|---|---|---|
| Armon Mason (DE) | Undisclosed | Out | |
| Billy Wilkes (LB) | Undisclosed | Out | |
| DeMonte Capehart (DT) | Undisclosed | Probable | |
| Easton Ware (OL) | Undisclosed | Out | |
| Elyjah Thurmon (OL) | Undisclosed | Out | |
| Jarvis Green (RB) | Foot | Out | |
| Jay Haynes (RB) | Quadriceps | Out | |
| Ricardo Jones (S) | Undisclosed | Probable |
Duke
| Player | Injury | Status | Details |
|---|---|---|---|
| Terry Moore (S) | Undisclosed | Out |
FSU
| Player | Injury | Status | Details |
|---|---|---|---|
| Chase Loftin (TE) | Hamstring | Questionable | |
| Deamontae Diggs (DL) | Undisclosed | Out | |
| Gunnar Hansen (OL) | Undisclosed | Probable | |
| Ja'Bril Rawls (DB) | Undisclosed | Out | |
| James Williams (DL) | Undisclosed | Probable | |
| Jayvan Boggs (WR) | Undisclosed | Probable | |
| Lawayne McCoy (WR) | Undisclosed | Probable | |
| Quindarrius Jones (DB) | Undisclosed | Out | |
| Roydell Williams (RB) | Undisclosed | Probable | |
| Samuel Singleton (RB) | Undisclosed | Questionable | |
| Teriq Mallory (WR) | Undisclosed | Probable |
Louisville
| Player | Injury | Status | Details |
|---|---|---|---|
| Grant Houser (TE) | Knee | Out | |
| Isaac Brown (RB) | Lower Leg | Out | |
| Jamarice Wilder (RB) | Undisclosed | Out | |
| Shammai Gates (RB) | Undisclosed | Out | |
| Stanquan Clark (LB) | Lower Leg | Probable | |
| Tayon Holloway (DB) | Undisclosed | Questionable | |
| Travis Egan (QB) | Undisclosed | Out |
Miami
| Player | Injury | Status | Details |
|---|---|---|---|
| Brock Schott (TE) | Undisclosed | Out | |
| David Blay (DL) | Undisclosed | Questionable | |
| Jack Nickel (TE) | Undisclosed | Out | |
| Keionte Scott () | Undisclosed | Out | |
| Tony Johnson () | Undisclosed | Out |
UNC
| Player | Injury | Status | Details |
|---|---|---|---|
| Aidan Banfield (OL) | Undisclosed | Out | |
| Chad Lindberg (OL) | Undisclosed | Out | |
| Christo Kelly (OL) | Undisclosed | Out | |
| Cort Halsey (TE) | Undisclosed | Out | |
| Deems May (TE) | Undisclosed | Out | |
| Kaleb Cost (DB) | Undisclosed | Questionable | |
| Thaddeus Dixon (DB) | Undisclosed | Questionable |
Notre Dame
| Player | Injury | Status | Details |
|---|---|---|---|
| Ashton Craig (OL) | Knee | Out | |
| Billy Schrauth (OL) | Knee | Out | |
| Charles Jagusah (OL) | Arm | Questionable | |
| Cooper Flanagan (TE) | Achilles | Questionable | |
| Dylan Devezin (RB) | Shoulder | Out | |
| Gabriel Rubio (DL) | Elbow | Questionable | |
| Jaden Greathouse (WR) | Hamstring | Out | |
| Jordan Botelho (DL) | Concussion | Questionable | |
| Kedren Young (RB) | Knee | Out | |
| Loghan Thomas (DL) | Concussion | Questionable | |
| Micah Gilbert (WR) | Hand | Questionable | |
| Noah Burnette (K) | Hip | Out |
Pittsburgh
| Player | Injury | Status | Details |
|---|---|---|---|
| Censere Lee (WR) | Redshirt | Out | |
| Denim Cook (DL) | Undisclosed | Questionable | |
| Jayden Bonsu (LB) | Undisclosed | Questionable | |
| Jaylin Brown (RB) | Undisclosed | Questionable | |
| Jeff Persi (OL) | Undisclosed | Questionable | |
| Keith Gouveia (OL) | Lower Leg | Out | |
| Rasheem Biles (LB) | Undisclosed | Questionable |
NC State
| Player | Injury | Status | Details |
|---|---|---|---|
| Cole Wilson (QB) | Undisclosed | Questionable | |
| Isiah Jones (RB) | Undisclosed | Out | |
| Jonathan Paylor (WR) | Undisclosed | Out | |
| Justin Joly (TE) | Leg | Questionable | |
| Sean Brown (LB) | Undisclosed | Out |
Syracuse
| Player | Injury | Status | Details |
|---|---|---|---|
| Chase Simmons (DL) | Undisclosed | Out | |
| Dan Villari (TE) | Lower Body | Questionable | |
| Derek McDonald (LB) | Undisclosed | Out | |
| Emanuel Ross (WR) | Undisclosed | Out | |
| Justus Ross-Simmons (WR) | Undisclosed | Questionable | |
| Malachi James (RB) | Undisclosed | Out | |
| Tyshawn Russell () | Undisclosed | Out |
Virginia
| Player | Injury | Status | Details |
|---|---|---|---|
| Chandler Morris (QB) | Concussion | Questionable | |
| Dakota Twitty (TE) | Leg | Out | |
| Drake Metcalf (OL) | Undisclosed | Probable | |
| Dre Walker (CB) | Undisclosed | Out | |
| Grady Brosterhous (QB) | Foot | Out | |
| Jahmeer Carter (DT) | Undisclosed | Probable | |
| Jayden Thomas (WR) | Ankle | Out | |
| Monroe Mills (OL) | Undisclosed | Out | |
| Noah Vaughn (RB) | Ankle | Out | |
| Suderian Harrison (WR) | Redshirt | Out | |
| Trevor Ladd (WR) | Undisclosed | Out | |
| Xavier Brown (RB) | Foot | Out |
Virginia Tech
| Player | Injury | Status | Details |
|---|---|---|---|
| Braydon Bennett (RB) | Undisclosed | Out | |
| Brody Meadows (OL) | Foot | Out | |
| Caleb Brown (CB) | Undisclosed | Out | |
| Chanz Wiggins (WR) | Undisclosed | Out | |
| Gabe Williams (LB) | Undisclosed | Questionable | |
| James Djonkam (DL) | Not Injury Related | Out | |
| Keylen Adams (WR) | Undisclosed | Out | |
| L.J. Booker (WR) | Undisclosed | Out | |
| Montavious Cunningham (OL) | Undisclosed | Out | |
| Quentin Reddish (S) | Undisclosed | Out | |
| Zeke Wimbush (TE) | Undisclosed | Questionable |
Wake Forest
| Player | Injury | Status | Details |
|---|---|---|---|
| Chris Barnes (WR) | Undisclosed | Questionable | |
| Clinton Richard (OL) | Undisclosed | Probable | |
| David Egbe (RB) | Undisclosed | Out | |
| Elijiah Oehlke (QB) | Undisclosed | Out | |
| Harry Lodge (TE) | Undisclosed | Probable | |
| Ian VerSteeg (WR) | Undisclosed | Out | |
| Wesley Stroebel (WR) | Undisclosed | Out |
