100 - 59 
The #20 Cardinals jumped out to a 10-0 lead and then cruised to a 100-59 win against the Panthers. Louisville made 15 of 29 three-pointers in the game, 11 of which came in the first half as the Cardinals took a 31-point lead heading into halftime. Ryan Conwell was the leading scorer with 24 points on 9-16 shooting, with five made three-pointers, six assists, and six rebounds. J'Vonne Hadley had 17 points, seven rebounds, and five assists. Isaac McKneely hit three three-pointers and scored 11 points. Brandin Cummings led Pitt with 11 points.
