Weekends filled with NFL action are like a football fan's version of a holiday, and this Sunday, January 11, 2026, promises thrilling matchups that could shake up the playoff picture. Let's dive into the top games to keep an eye on and what our GameSim predictions say about each nail-biting encounter.
Buffalo Bills at Jacksonville Jaguars
First up, we have the Buffalo Bills heading south to face off against the Jacksonville Jaguars. Both teams are neck-and-neck with the Jaguars having a slight edge, predicted to win 26.1 to 25.4. With a razor-thin 51% win probability, this game is practically a toss-up. The full prediction is worth a look.
Quarterback duels are always a spectacle, and this game features Josh Allen and Trevor Lawrence, both projected to have strong performances. Allen is expected to throw for 253.6 yards and 1.9 touchdowns, while Lawrence is right behind with 241.7 yards and the same number of touchdowns. On the ground, watch out for James Cook and Travis Etienne, both forecasted to rush for over 72 yards, possibly tipping the scales in their teams' favor.
San Francisco 49ers at Philadelphia Eagles
Next, the San Francisco 49ers take on the Philadelphia Eagles in a game that promises fireworks. Our model gives the Eagles a clear advantage with a 62% win probability and a predicted score of 28.8 to 20.3. The Eagles are favored by Vegas too, with a spread of -4.5, adding more spice to the contest. See the complete breakdown.
Brock Purdy of the 49ers is expected to air it out with a massive 290.5 yards and 2.2 touchdowns. Meanwhile, Jalen Hurts will lead the charge for the Eagles, aiming for 231.2 passing yards and matching Purdy's touchdown output. On the ground, Saquon Barkley is projected to rush for 74.4 yards, a crucial component of the Eagles' game plan. Christian McCaffrey will need to find a way to impact the game despite a modest rushing projection of 42.2 yards.
Los Angeles Chargers at New England Patriots
Rounding out the marquee matchups is the clash between the Los Angeles Chargers and the New England Patriots. The Patriots are favored with a 61% win probability and a predicted scoreline of 31.7 to 23.9. This game could be pivotal for playoff positioning. Dive into the full details.
Rookie sensation Drake Maye is set to impress for New England, with a projected 296 passing yards and 2.3 touchdowns. His counterpart, Justin Herbert, isn’t far behind with 280.6 yards and 2.2 touchdowns. On the ground, watch for TreVeyon Henderson, who could be a game-changer with an expected 57.2 rushing yards and half a touchdown.
For those eager to dive deeper into the numbers, detailed projected player stats for all games are available exclusively to GameSim+ subscribers. Check out GameSim+ to get the inside scoop and enhance your game day experience.
