The 2021 Duke's Mayo Bowl will be a battle between the Carolinas, to be played in Charlotte, North Carolina. This will be the 59th meeting between North Carolina and South Carolina, with the Tar Heels holding a 35-19-4 series advantage over the Gamecocks. Sam Howell will look to lead North Carolina to its 16th all-time bowl win in what could be his final game in a UNC uniform. Get set to watch these to border rivals square off right here!